![]() ![]() ![]() Objectives The present study was designed to compare the effects of alprazolam XR (1 mg) and alprazolam IR (1 mg) on actual driving ability and cognitive function. The effect of alprazolam XR on potentially dangerous daily activities, such as driving a car, is expected to be less as compared to alprazolam IR. This sustained formulation is absorbed in a delayed manner and is therefore expected to produce fewer and less severe side effects than its immediate release equivalent (alprazolam IR). Rationale Alprazolam extended-release (XR) is approved for the treatment of panic disorder. Exploratory analysis in a small group of poor CYP 2D6 metabolizers suggested that these subjects are more sensitive to the impairing effects of esmirtazapine on car driving. Single-dose administration of 4.5 mg esmirtazapine was associated with residual impairment that generally resolved after repeated administration. CONCLUSION: It is concluded that single and repeated doses of 1.5 mg esmirtazapine are generally not associated with residual impairment. A single-dose zopiclone 7.5 mg also increased SDLP as expected. ![]() Acute driving impairment was more pronounced after both doses of esmirtazapine in a select group of poor metabolizers (N = 7). Driving impairment, i.e., a rise in SDLP, did occur after a single-dose administration of esmirtazapine 4.5 mg but was resolved after repeated doses. RESULTS: Overall, esmirtazapine 1.5 mg did not produce any clinically relevant change in SDLP after single and repeated dosing. ![]() All subjects were subjected to CYP2D6 phenotyping in order to distinguish poor metabolizers from extensive metabolizers of esmirtazapine. The primary study parameter was standard deviation of lateral position (SDLP), a measure of "weaving". Driving performance was assessed in the morning, 11 h after drug intake, in a standardized on-the-road highway driving test. METHODS: Treatments were administered in the evening. Treatment with single doses of zopiclone 7.5 mg was included as active control. PURPOSE: The present study was designed to assess residual effects of single and repeated doses of esmirtazapine 1.5 and 4.5 mg on actual driving in 32 healthy volunteers in a double-blind, placebo-controlled study. INTRODUCTION: Esmirtazapine is evaluated as a novel drug for treatment of insomnia. ![]()
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